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Because statins decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, ZETIA in combination with a statin may cause fetal harm when administered to pregnant women.
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Schering-Plough pharmaceuticals venture, said Vytorin will successfully compete against generics because it meets the aggressive physician guidelines in reducing low-density lipoprotein cholesterol, also known as "bad" cholesterol.
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It was at the advice of my cardiologist that I started taking it and it helped in lowering my cholestral.
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When all patients receiving ZETIA with an HMG-CoA reductase inhibitor were compared to all those receiving the corresponding HMG-CoA reductase inhibitor alone, ZETIA significantly lowered total-C, LDL-C, Apo B, and TG, and, with the exception of pravastatin, increased HDL-C compared to the HMG-CoA reductase inhibitor administered alone.
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Few serious adverse events were reported, but several were reported in patients treated with infliximab or secukinumab.
Both ezetimibe and ezetimibe-glucuronide are slowly eliminated from plasma with a half-life of approximately 22 hours for both ezetimibe and ezetimibe-glucuronide.
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