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There is moderate quality evidence that with use up to 60 days, the incidence of serious adverse events is not significantly greater than for placebo in the identified trials.

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Vries PJBN, Van Thien H, Hung LN, Anh TK, Kager PA, Heisterkamp SH: Combinations of artemisinin and quinine for uncomplicated falciparum malaria: efficacy and pharmacodynamics.

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For someone already ill, it is given once a day for three days, preferably in combination with a new malaria drug (the artemisinin derivative, artesunate) that has been in driving down global illness.

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Quinine is used alone or with other medications to treat malaria (a serious or life-threatening illness that is spread by mosquitos in certain parts of the world).

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Antiepileptics (AEDs) (carbamazepine, phenobarbital, and phenytoin): Carbamazepine, phenobarbital, and phenytoin are CYP3A4 inducers and may decrease quinine plasma concentrations if used concurrently with quinine sulfate capsules, USP.

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