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In a steady-state study in which healthy elderly subjects (age 65 to 81 years old) were given 500 mg of clarithromycin every 12 hours, the maximum serum concentrations and area under the curves of clarithromycin and 14-OH clarithromycin were increased compared to those achieved in healthy young adults.

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Clarithromycin is active in vitro against a variety of aerobic and anaerobic Gram-positive and Gram-negative bacteria as well as most Mycobacterium avium complex (MAC) bacteria.

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In both of these studies, discontinuation of azithromycin prophylaxis was not found to increase the incidence of MAC disease significantly during a median of 12-16 months of follow-up, suggesting that it is safe to discontinue primary prophylaxis in those patients who have had a CD4 T-cell count recovery attributed to ART.

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