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I was on Celexa then Zoloft for post traumatic stress disorder and they left me feeling like I was in the bottom of a well looking up. Mirtazapine makes me feel human again.



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What about self-help and home remedies for depression?

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Antidepressant Use in Pregnancy and the Risk of Cardiac Defects".

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Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mirtazapine in the elderly.

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Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J; Drug-Induced Liver Injury Network(DILIN).

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This response rate is somewhat less than a previously reported rate of 48% in a study of outpatients who did not respond to fluoxetine, paroxetine or sertraline for at least 4 weeks at standard doses and then were subsequently switched to open-label mirtazapine at a flexible dose (i.

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My point is you did not explicitly, and a stress the word explicitly, warn that medication should only be used as a last resort.

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Overall, these studies demonstrated mirtazapine to be superior to placebo on at least 3 of the following 4 measures: 21 Item Hamilton Depression Rating Scale (HDRS) total score; HDRS Depressed Mood Item; CGI Severity score; and Montgomery and Asberg Depression Rating Scale (MADRS).

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Sixteen patients dropped out of the study before reaching the last visit because of side-effects and medical complications as a result of HIV infection, but completing patients (41%) showed a statistically significant improvement in all measures.

Patients should be closely monitored for symptoms of the serotonin syndrome during treatment.

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Two meta-analyses published in 2008 (Kirsch) and 2010 (Fournier) found that in mild and moderate depression, the effect of SSRIs is small or none compared to placebo, while in very severe depression the effect of SSRIs is between "relatively small" and "substantial".

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