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After ten years, the incidence of diabetes was 34% lower in the group of participants given diet and exercise and 18% lower in those given metformin.
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ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amiloride; beta-blockers (eg, propranolol); cimetidine; digoxin; morphine; procainamide; quinidine; quinine; ranitidine; triamterene; trimethoprim; vancomycin; calcium channel blockers (eg, nifedipine); corticosteroids (eg, prednisone); diuretics (eg, furosemide, hydrochlorothiazide); estrogen; hormonal contraceptives (eg, birth control pills); insulin; isoniazid; nicotinic acid; phenothiazines (eg, chlorpromazine); phenytoin; sulfonylureas (eg, glipizide); sympathomimetics (eg, albuterol, pseudoephedrine); thyroid hormones (eg, levothyroxine); or medicines that may harm the kidney (eg, aminoglycoside antibiotics, such as gentamicin; amphotericin B; tacrolimus).
CONCLUSIONS In our study, cumulative exposure to metformin was associated with a lower risk of specific cancers and cancer in general, compared with cumulative exposure to sulfonylurea derivatives.
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Some metabolic actions of metformin do appear to occur by AMPK-independent mechanisms; the metabolic actions of metformin in the heart muscle can occur independent of changes in AMPK activity and may be mediated by - and -dependent mechanisms.
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Evaluate renal function prior to initiation of therapy and at least annually thereafter.
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Metformin inhibits the growth of cancer cells in vitro and tumors in vivo.
Inform your doctor if you drink alcohol or have a history of heart problems, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, lactic acidosis, or alcohol abuse.
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Berberine mimics insulin action by increasing glucose uptake ability by 3T3-L1 adipocytes (fat cells) and L6 myocytes (muscle cells) in an insulin-independent manner.
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Metformin will cause a few pounds of weight loss that aren't fat, but seem to be the weight of glycogen stored in your liver (the same weight you lose on the first days of a low carb diet).
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